The Claisen rearrangement is an organic reaction where an allyl vinyl ether is converted into a γ,δ-unsaturated carbonyl compound with the input of heat or a Lewis acid. Buy3-Hydroxycyclobutan-1-one This reaction belongs to a class of reactions termed “sigmatropic rearrangements” and it is a concerted process where bonds are forming and breaking at the same time. When substituents are present in the allyl vinyl ether starting material, the stereochemistry of this reaction can be predicted by drawing the molecule in a chair-like conformation and placing the substituents in the equatorial position to minimize the steric interactions. Formula of 1146118-59-3 [1][2]
Mechanism
References:
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Claisen, L. Ber. Dtsch. Chem. Ges. 1912, 45, 3157–3166.
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2. |
Claisen, L.; Eisleb, O. Justus Liebigs Ann. Chem. 1913, 401, 21–119.
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