Also known as: Curtius degradation
The Curtius rearrangement is an organic reaction used to convert an acyl azide to an isocyanate under thermal conditions. N-Boc-PEG4-bromide Price The mechanism consists of an alkyl shift of the R group from the carbonyl carbon to the closest nitrogen with the release of nitrogen gas. 7-Bromo-1H-indole-6-carbonitrile custom synthesis The release of gas drives the reaction forward and results in the formation of the isocyanate product which can potentially react further in the presence of nucleophiles in solution. [1][2][3]
Mechanism
References:
| 1. |
Curtius, T. Ber. Dtsch. Chem. Ges. 1890, 23, 3023–3033.
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| 3. |
Curtius, T. J. Prakt. Chem. 1894, 50, 275–294.
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