The Kumada cross-coupling reaction is the organic reaction of an organohalide with an organomagnesium compound, also known as a Grignard reagent, to give the coupled product using a palladium or nickel catalyst. Formula of 1210833-53-6 The palladium catalyzed mechanism begins with oxidative addition of the organohalide to the Pd(0) to form a Pd(II) complex. 4,6-Dichloropyrimidin-5-ol web Transmetalation with the Grignard reagent then follows, where the R group of the Grignard reagent replaces the halide anion on the palladium complex and makes a magnesium(II) halide salt. Reductive elimination then gives the final coupled product, regenerates the catalyst, and the catalytic cycle can begin again. ^[1]