The Mannich reaction is an organic reaction used to convert a primary or secondary amine and two carbonyl compound (one non-enolizable and one enolizable) to a β-amino carbonyl compound, also known as a Mannich base, using an acid or base catalyst. 55206-24-1 Formula 7-Bromo-4-chloroquinolin-3-amine Order In the acid catalyzed mechanism both carbonyl compounds get protonated at the oxygen. The enolizable carbonyl compound, which has an α-hydrogen, then gets deprotonated to form an enol intermediate. The non-enolizable carbonyl compound reacts with the amine to form an iminium ion. The enol intermediate then attacks the iminium ion which after deprotonation provides the final Mannich base product. ^[1]