The Negishi cross-coupling reaction is the organic reaction of an organohalide with an organozinc compound to give the coupled product using a palladium or nickel catalyst. Lenalidomide-F custom synthesis The palladium catalyzed mechanism begins with oxidative addition of the organohalide to the Pd(0) to form a Pd(II) complex. 1396215-84-1 supplier Transmetalation with the organozinc then follows where the R group of the organozinc reagent replaces the halide anion on the palladium complex and makes a zinc(II) halide salt. Reductive elimination then gives the final coupled product, regenerates the catalyst, and the catalytic cycle can begin again. ^[1]