The Ritter reaction is an organic reaction used to convert a nitrile and a carbocation precursor (such as a substituted olefin or tertiary alcohol) to an amide using a strong acid and water. The mechanism begins with the formation of the carbocation from the reaction of the acid with the carbocation precursor. 1220019-95-3 manufacturer tert-Butyl 3-(methylamino)propanoate Price The nitrile then attacks the carbocation to form a nitrilium ion. Water hydrolysis and a series of proton transfer steps then yield the final amide product. [1][2]
Mechanism
References:
| 1. |
Ritter, J. J.; Minieri, P. P. J. Am. Chem. Soc. 1948, 70, 4045–4048.
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| 2. |
Ritter, J. J.; Kalish, J. J. Am. Chem. Soc. 1948, 70, 4048–4050.
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