The Wagner-Meerwein rearrangement is an organic reaction used to convert an alcohol to an olefin using an acid catalyst. The mechanism begins with protonation of the alcohol by the acid which is then released as water to forms a carbocation. 6-Bromopyrazin-2-amine web 8-Bromoimidazo[1,5-a]pyridine In stock A 1,2-shift then occurs to form a more substituted and stabilized carbo-cation. A final deprotonation with water produces the final olefin product and regenerates the acid catalyst. [1][2]
Mechanism
References:
| 1. |
Wagner, G. J. Russ. Phys. Chem. Soc. 1899, 31, 690
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| 2. |
Meerwein, H. Justus Liebigs Ann. Chem. 1914, 405, 129–175.
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