twenty Might 2013 Accepted: 24 July 2013 Published: 24 July 2013 References one. Kavanagh BP, McCowen KC: Clinical practice: glycemic management in the ICU. N Engl J Med 2010, 363(26):2540-2546. two. Krinsley JS: Understanding glycemic handle inside the critically sick: three domains are superior than one. Intensive Care Med 2011, 37(three):382-384. three. Krinsley JS: Association in between hyperglycemia and elevated hospital mortality within a heterogeneous population of critically unwell individuals. Mayo Clin Proc 2003, 78(12):1471-1478. four. Bochicchio GV, Joshi M, Bochicchio KM, Pyle A, Johnson SB, Meyer W, Lumpkins K, Scalea TM: Early hyperglycemic control is important in critically injured trauma individuals. J Trauma 2007, 63(six):1353-1358, discussion, 1358-1359. 5. Bagshaw SM, Egi M, George C, Bellomo R, Australia New Zealand Intensive Care Society Database Management C: Early blood glucose handle and mortality in critically unwell sufferers in Australia.Perfluoroundecanoic acid Chemscene Crit Care Med 2009, 37(two):463-470. 6. NICE-SUGAR Research Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hebert Computer, Heyland DK, Robinson BG: Hypoglycemia and threat of death in critically sick sufferers. N Engl J Med 2012, 367(12):1108-1118. 7. Hermanides J, Bosman RJ, Vriesendorp TM, Dotsch R, Rosendaal FR, Zandstra DF, Hoekstra JB, DeVries JH: Hypoglycemia is linked with intensive care unit mortality. Crit Care Med 2010, 38(6):1430-1434. eight. Egi M, Bellomo R, Stachowski E, French CJ, Hart G: Variability of blood glucose concentration and short-term mortality in critically unwell individuals. Anesthesiology 2006, 105(two):244-252. 9. Krinsley JS: Glycemic variability: a powerful independent predictor of mortality in critically ill patients. Crit Care Med 2008, 36(eleven):3008-3013. 10. Badawi O, Waite MD, Fuhrman SA, Zuckerman IH: Association involving intensive care unit-acquired dysglycemia and in-hospital mortality.1319716-42-1 custom synthesis Crit Care Med 2012, 40(12):3180-3188.PMID:24120168 11. Dungan KM, Braithwaite SS, Preiser JC: Tension hyperglycaemia. Lancet 2009, 373(9677):1798-1807.Important messages ?Completely automated closed-loop glucose management determined by subcutaneous sensor glucose is possible. ?Closed-loop treatment method provided secure, productive, and constant glucose control with no growing the danger of hypoglycemia in the small group of individuals more than a 48-hour period. ?Closed-loop treatment method was superior to a neighborhood sliding-scale remedy protocol. ?Nurse intervention will not be expected through closed-loop treatment method, other than calibrating a subcutaneous glucose monitor. ?Automated administration of dextrose augmented the potential of closed-loop remedy to avoid low glucose amounts.Abbreviations CGM: Steady glucose monitoring; CL: closed-loop; NCCU: Neurosciences Vital Care Unit at Addenbrooke’s Hospital: Cambridge: Uk.Leelarathna et al. Critical Care 2013, 17:R159 http://ccforum/content/17/4/RPage eleven of12. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R: Intensive insulin therapy in critically sick patients. N Engl J Med 2001, 345(19):1359-1367. 13. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, Bobbaers H, Bouillon R: Intensive insulin treatment from the health care ICU. N Engl J Med 2006, 354(five):449-461. 14. NICE-SUGAR Review Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, Cook D, Dodek P, Hend.